Present Position and Address

6.144 Medical Research Bldg.
Mail Route:1079
Telephone: (409)747-0387
Fax: (409) 747-8608
Email: tgwood@utmb.edu

B.S. 1969 Indiana University of Pennsylvania
Ph.D. 1974 University of Texas

RESEARCH INTERESTS:

The Recombinant DNA Laboratory (RDL) is a Core Facility in the Sealy Center for Molecular Science. The RDL offers a wide variety of technical services designed to benefit and enhance the research programs at the University of Texas Medical Branch. RDL services are available on a cost-recovery per item charge basis. Technical services include plasmid DNA preparation, transformation and screening, phage DNA (lambda and M13) purification, competent cell preparation, isolation of eukaryotic DNA or RNA, and DNA sequence analysis. Technical expertise in vector/plasmid construction, genomic and cDNA library construction, polymerase chain reaction techniques, bacterial expression, and various types of mutagenesis (deletion, replacement and site-directed) is available.

The Molecular Genomics (MG) Core provides technical support in the area of mRNA expression profiling. The Core offers expression analysis using Affymetrix Gene Chip technology and custom microarray production and analysis. The microarray facility has a BioRad robotic spotter for production of glass-slide based microarrays. Fluidic support is provided by a Beckman Biomek FX robot and analysis is performed using a Gene Pix Pro 4.0 Scanner (Axon Instruments). Core support in probe design, probe isolation, probe amplification, microarray spotting, hybridization and analysis is available.

1. Glasgow, J.N., Qiu, J., Rassin, D., Grafe, M., Wood, T. and Perez-Polo, J.R. Transcriptional regulation of the BDL-X gene by NF-kB is an element of hypoxic responses in the rat brain. Neurochem. Research, 26: 647-659, 2001.
2. Cobb, S., Wood, T., Tessarollo, L., Valeasco, M., Given, R., Varro, A., Tarasova, N. and Singh, P. Deletion of functional gastrin gene markedly increases colon Carcinogenesis in response to azoxymethane in mice. Gastroenterology, 123: 516-530, 2002.
3. Thomas, R.P., Guigneaux, M., Wood, T., and Evers, B.M. Age-associated changes in gene expression patterns in the liver. Journal of Gastrointestinal Surgery, 6: 445-454, 2002.
4. Urban, R.J., Bodenburg, Y.H. and Wood, T.G. NH2 terminus of PTB-associated splicing factor binds to the porcine P450SCC IGF-I response element. Am.J. Physiol. Endocrinol. Metab. 283: 423-427, 2002.
5. Webb, M.S., Miller, A.L., Johnson, B.H., Fofanov, Y., Li, T., Wood, T.G. and Thompson, E.B. Gene networks in glucocorticoid-evoked apoptosis of leukemic cells. J. Steroid Biochem. Mol. Biol., 85: 183-193, 2003.
6. Medh, R.D., Webb, M.S., Miller, A.L., Johnson, B.H., Fofanov, Y., Li, T., Wood, T.G., Luxon, B.A. and Thompson, E.B. Gene expression profile of human lymphoid CEM cells sensitive and resistant glucocorticoid-evoked apoptosis. Genomics, 81: 543-555, 2003.